Today, we have the Single Page Application (SPA). Most web apps are now in the browsers themselves, and the web is becoming fluid, comfortable, and accessible from any device. Learn SPA design approach and then start exploring new techniques like structured JavaScript and responsive design. This talk also covers server-side JavaScript, NoSQL data stores, and new JavaScript frameworks.
Slides of the presentation: http://html5devconf.com/archives/october2012/slides/Michael-S-Mikowski-Tuesday-2012-10-16-js4spa.pdf